In vitro adherence of Candida albicans to human corneocytes. Inhibition by chitin-soluble extract

In vitro adherence of Candida albicans to human corneocytes and the effect of a chitin-soluble extract (CSE) on the adherence reaction were studied. Adherence of the yeasts to cells obtained from different individuals was variable. However, repeated adherence tests with pooled corneocytes of 2 individuals from this group showed that the adherence parameters did not differ greatly throughout these tests. CSE at the concentration of 50 mg/ml had a significant inhibitory effect on the attachment of C. albicans to the corneocytes, most probably by blocking their receptors of attachment. The data indicate that the preparation may be useful in the prophylactive management of recurrent cutaneous candidiasis in susceptible individuals.