Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluosol and experimental spinal cord ischemia.

S Kolluri1, U DeGirolami, R Heros

  • 1Department of Surgery (Neurosurgery), Massachusetts General Hospital/Harvard Medical School, Boston 02114.

Acta Neuropathologica
|January 1, 1988
PubMed
Summary

This study investigated Fluosol DA and Dextran 40 treatments for spinal cord ischemia in rabbits. Neither treatment improved neurological outcomes or reduced spinal cord infarction compared to controls.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Not Available].

Annales de genetique et de selection animale·2012
Same author

[Not Available].

Annales de genetique et de selection animale·2012
Same author

Endoscopic approach to intraventricular cysticercal lesions.

Minimally invasive neurosurgery : MIN·2002
Same author

Operative results without invasive monitoring in patients with frontal lobe epileptogenic lesions.

Epilepsia·2001
Same author

Preeclampsia-eclampsia: clinical and neuroradiographic correlates and insights into the pathogenesis of hypertensive encephalopathy.

Radiology·2000
Same author

Evaluation of posttraumatic vasospasm, hyperaemia, and autoregulation by transcranial colour-coded duplex sonography.

British journal of neurosurgery·2000

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Regenerative Medicine

Background:

  • Spinal cord ischemia is a serious complication following aortic procedures.
  • Current treatments for spinal cord ischemia have limited efficacy.
  • Developing effective neuroprotective strategies is crucial.

Purpose of the Study:

  • To evaluate the efficacy of Fluosol DA 20% and Dextran 40 in preventing spinal cord infarction after temporary aortic occlusion.
  • To compare the neuroprotective effects of Fluosol DA with 100% oxygen versus room air.
  • To assess the impact of these interventions on neurological outcomes and histological damage.

Main Methods:

  • Spinal cord ischemia was induced in 27 rabbits via temporary aortic occlusion (12.5 min).
  • Animals were divided into three groups receiving Fluosol DA (with 100% oxygen or room air) or Dextran 40 (with 100% oxygen).

Related Experiment Videos

  • Neurological function and spinal cord infarction severity were assessed post-intervention.

    • Main Results:

    • No significant differences in neurological outcome were observed between the Fluosol DA and Dextran 40 groups.
    • Histological analysis revealed no reduction in the extent or severity of spinal cord infarction in treated groups.
    • Outcomes were comparable to previously studied untreated control groups.

    Conclusions:

    • Fluosol DA 20% and Dextran 40 did not demonstrate neuroprotective effects against spinal cord ischemia in this rabbit model.
    • Neither oxygenation level (100% or room air) influenced the efficacy of Fluosol DA.
    • Further research is needed to identify effective treatments for preventing spinal cord injury during aortic procedures.