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Related Experiment Videos

Reversible conductive hearing loss in mice.

L J Hood1, D B Webster

  • 1Kresge Hearing Research Laboratory of the South, Department of Otorhinolaryngology, Louisiana State University Medical Center, New Orleans 70112.

The Annals of Otology, Rhinology, and Laryngology
|May 1, 1988
PubMed
Summary
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Fibrin tissue adhesive temporarily reduced auditory sensitivity in mice, with hearing returning to normal within 26 days. This study monitored auditory brain stem responses (ABRs) after injection.

Area of Science:

  • Otolaryngology
  • Biomaterials Science
  • Auditory Neuroscience

Background:

  • Fibrin tissue adhesives are used clinically for hemostasis and tissue sealing.
  • The otologic effects of fibrin sealant have not been extensively studied.
  • Understanding potential impacts on auditory function is crucial for clinical applications.

Purpose of the Study:

  • To investigate the effects of fibrin tissue adhesive injection into the middle ear on auditory sensitivity in mice.
  • To assess the temporal dynamics of hearing changes and recovery following fibrin sealant application.

Main Methods:

  • Fibrin tissue adhesive was injected into the right middle ear of CBA/J mice.
  • Auditory brain stem responses (ABRs) were recorded over 26 days to monitor auditory sensitivity.

Related Experiment Videos

  • Histological examination of the middle ear and cochlea was performed post-study.

    • Main Results:

    • Maximum auditory brain stem response (ABR) threshold shifts reached up to 36 dB.
    • Hearing impairment was more pronounced at higher frequencies compared to lower frequencies.
    • Auditory sensitivity returned to pre-injection levels by day 26.

    Conclusions:

    • Middle ear injection of fibrin tissue adhesive can cause temporary, frequency-dependent hearing loss in mice.
    • The auditory system demonstrated recovery within 26 days, suggesting the effects are reversible.
    • Further research is warranted to evaluate long-term effects and safety in otologic procedures.