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Updated: Aug 2, 2026
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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
Published on: July 17, 2018
Angiogenic activity of adipose tissue
K J Silverman1, D P Lund, B R Zetter
1Department of Physiology, Harvard Medical School, Boston, MA 02115.
Biochemical and Biophysical Research Communications
|May 31, 1988
Summary
Adipose tissue promotes blood vessel growth (angiogenesis) in the cornea. This effect, linked to prostaglandins, was blocked by indomethacin, suggesting a new therapeutic pathway.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Tissue Engineering
Background:
- Adipose tissue is recognized for its therapeutic potential in wound healing and myocardial revascularization.
- The angiogenic properties of adipose tissue require further investigation across different anatomical sites.
Purpose of the Study:
- To investigate the angiogenic capacity of adipose tissue from various sources within the corneal microenvironment.
- To elucidate the role of prostaglandins in fat-induced angiogenesis in the cornea.
Main Methods:
- Rabbit subcutaneous and omental fat were implanted into rabbit corneas.
- Control implants included liver and muscle tissue.
- Indomethacin was administered to assess the involvement of prostaglandins in the angiogenic response.
Main Results:
- Subcutaneous and omental fat induced significant and comparable neovascularization in rabbit corneas.
- Control tissues (liver, muscle) did not elicit a neovascularization response.
- Indomethacin administration blocked fat-induced corneal neovascularization, indicating prostaglandin involvement.
Conclusions:
- Adipose tissue possesses potent angiogenic properties in the cornea.
- Prostaglandins play a crucial role in mediating fat-induced angiogenesis.
- These findings suggest potential applications of adipose tissue in treating avascular corneal conditions.
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