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In Vitro Drug Dissolution: Alternative Methods

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...

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Agar diffusion methods for the assay of viomycin

J EHRLICH, W P IVERSON, D KOHBERGER

Antibiotics & Chemotherapy (Northfield, Ill.)

|February 19, 2014

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No abstract available in PubMed .

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