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Substance P-dopamine relationship in the rat substantia nigra: a light and electron microscopy study of double
1Department of Anatomy and Neurobiology, University of Tennessee, Memphis, College of Medicine 38163.
Brain Research
|May 17, 1988
Abstract:
The synaptic relationships between substance P-containing terminals and dopaminergic neurons (immunoreactive for tyrosine hydroxylase) in the substantia nigra were studied at both light and electron microscopic levels using a pre-embedding double-labeling immunocytochemical method. Many substance P-containing terminals were found to form synapses directly with dendrites and somata of nigral dopaminergic neurons. Since most of the substance P-containing axon terminals arise from the striatum, this result suggests that striatal substance P neurons can have monosynaptic influence on nigral dopaminergic neurons.