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Genetic amniocentesis in twin pregnancies
L Pijpers1, M G Jahoda, R P Vosters
1Department of Obstetrics and Gynaecology, Academic Hospital, Rotterdam Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
British Journal of Obstetrics and Gynaecology
|April 1, 1988
Summary
Genetic amniocentesis is safe for twin pregnancies. However, elevated alpha-fetoprotein (AFP) levels require careful interpretation due to diffusion between amniotic sacs.
Area of Science:
- Perinatology
- Medical Genetics
- Obstetrics
Background:
- Twin pregnancies present unique challenges for prenatal diagnosis.
- Prenatal genetic studies are crucial for identifying potential fetal abnormalities.
Purpose of the Study:
- To evaluate the safety and reliability of genetic amniocentesis in twin pregnancies.
- To assess the implications of alpha-fetoprotein (AFP) levels in twin gestation.
Main Methods:
- Retrospective analysis of 83 twin pregnancies undergoing prenatal genetic studies.
- Successful amniotic fluid collection from both sacs in 77 cases.
- Monitoring of pregnancy outcomes and perinatal mortality.
Main Results:
- No abnormal karyotypes were detected in the studied twin pregnancies.
- Elevated AFP levels were observed in two pregnancies, with varied outcomes.
- Perinatal mortality rate was 55/1000 (9 of 164 fetuses).
Conclusions:
- Genetic amniocentesis is a safe and reliable procedure for twin pregnancies.
- Elevated AFP levels in twin pregnancies necessitate cautious interpretation due to inter-sac diffusion.