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Anatomical evidence for a strong ventral parabrachial projection to nucleus raphe magnus and adjacent tegmental field
1Department of Anatomy, School of Medicine, University of California, San Francisco 94143.
Abstract:
Injections with [3H]leucine in the ventral parabrachial nuclei and nucleus Kölliker-Fuse of the cat revealed strong projections to the nucleus raphe magnus (NRM) and adjacent tegmentum, while similar injections in the adjacent nucleus subcoeruleus produced diffuse projections to large parts of the tegmentum, but not specifically to the NRM. Horseradish peroxidase (HRP) injections in the area of the NRM and adjacent tegmentum demonstrated many labeled neurons in the ventral parabrachial nuclei, nucleus Kölliker-Fuse and nucleus subcoeruleus. These results suggest that the inhibition of nociception induced by stimulation in the ventral parabrachial nuclei may be based on the projections of this area to NRM and adjacent tegmentum.