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Response to pneumococcal vaccination in mannose-binding lectin-deficient adults with recurrent respiratory tract

D A van Kessel1, T W Hoffman, H van Velzen-Blad

  • 1Department of Pulmonology, Sint Antonius Hospital, Nieuwegein, the Netherlands; Division of Heart and Lungs, University Medical Center, Utrecht, the Netherlands.

Clinical and Experimental Immunology
|February 20, 2014
PubMed

Insights

Mannose-binding lectin (MBL)-deficiency increases infection risk. This study found MBL-deficient adults with recurrent respiratory tract infections (RRTI) show a comparable antibody response to pneumococcal vaccination as MBL-sufficient individuals.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Mannose-binding lectin (MBL)-deficiency is linked to higher susceptibility to infections, particularly pneumococcal diseases.
  • Pneumococcal vaccination is advised for MBL-deficient patients experiencing recurrent respiratory tract infections (RRTI).
  • The immune response to pneumococcal vaccines in MBL-deficient individuals requires further investigation.

Purpose of the Study:

  • To assess the antibody response to pneumococcal vaccination in MBL-deficient adult patients with RRTI.
  • To compare the clinical presentation of MBL-deficient and MBL-sufficient patients with RRTI.

Main Methods:

  • Eighteen MBL-deficient and 63 MBL-sufficient adult patients with RRTI received the 23-valent pneumococcal polysaccharide vaccine.
  • Antibodies against 14 pneumococcal serotypes were quantified using a Luminex platform.
  • Clinical, radiological, lung function, and medication data were analyzed for differences between groups.

Main Results:

  • No significant difference was observed in the antibody response to pneumococcal vaccination between MBL-sufficient and MBL-deficient patients.
  • The proportion of responders versus low responders to the vaccine was similar across both groups.
  • No clear distinctions in clinical presentation, lung function, or medication use were found between MBL-deficient and MBL-sufficient patients with RRTI.

Conclusions:

  • MBL-deficient adults with RRTI exhibit a comparable immune response to pneumococcal polysaccharide vaccination as their MBL-sufficient counterparts.
  • MBL deficiency does not appear to have a distinct clinical role in adult RRTI based on this study.
  • Pneumococcal vaccination may offer protection against pneumococcal infections in MBL-deficient patients with RRTI, despite comparable vaccine response.
Keywords:
antibodiesimmunodeficiency diseasesmannose binding lectinpneumococcal vaccination

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