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Published on: July 6, 2019
Lysophosphatidic acid and apolipoprotein A1 predict increased risk of developing World Trade Center-lung injury: a
Jun Tsukiji1, Soo Jung Cho, Ghislaine C Echevarria
1Division of Pulmonary, Critical Care and Sleep Medicine, School of Medicine, New York University , New York, NY , USA .
Rationale:
Metabolic syndrome, inflammatory and vascular injury markers measured in serum after World Trade Center (WTC) exposures predict abnormal FEV1. We hypothesized that elevated LPA levels predict FEV₁ < LLN.
Methods:
Nested case-control study of WTC-exposed firefighters. Cases had FEV₁ < LLN. Controls derived from the baseline cohort. Demographics, pulmonary function, serum lipids, LPA and ApoA1 were measured.
Results:
LPA and ApoA1 levels were higher in cases than controls and predictive of case status. LPA increased the odds by 13% while ApoA1 increased the odds by 29% of an FEV₁ < LLN in a multivariable model.
Conclusions:
Elevated LPA and ApoA1 are predictive of a significantly increased risk of developing an FEV₁ < LLN.
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