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Updated: May 2, 2026
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Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.
Published on: March 17, 2008
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Evolution of implantable and insertable drug delivery systems
Lothar W Kleiner1, Jeremy C Wright2, Yunbing Wang3
1POLTECO Inc., Hayward, CA 94545, USA.
Summary
Implantable and insertable drug delivery systems (IDDS) have evolved significantly since the 1960s, offering diverse applications in treating vascular diseases, cancer, and eye conditions.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmacology
Background:
- Implantable and insertable drug delivery systems (IDDS) have a long history, originating in the 1960s.
- These systems are crucial for sustained and targeted therapeutic interventions.
- Advancements in materials and design have expanded their capabilities.
Purpose of the Study:
- To provide a comprehensive overview of the historical development of IDDS.
- To summarize the characteristics and applications of both non-degradable and biodegradable IDDS.
- To discuss the challenges and future prospects of IDDS technology.
Main Methods:
- Literature review and historical analysis of IDDS development.
- Categorization of IDDS into non-degradable and biodegradable types.
- Examination of IDDS applications across various medical fields.
Main Results:
- Detailed summary of non-degradable and biodegradable IDDS evolution.
- Exploration of IDDS applications in vascular disease, birth control, cancer, and eye treatments.
- Description of implantable pump systems and other atypical IDDS.
Conclusions:
- IDDS have progressed from basic designs to sophisticated systems.
- Biodegradable and non-degradable IDDS offer versatile solutions for chronic disease management.
- Future research should focus on overcoming current challenges to further enhance IDDS efficacy and patient outcomes.
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