Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

482
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
482
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.6K
Disorders of Hemostasis01:24

Disorders of Hemostasis

2.7K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.7K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.7K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.7K
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

415
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
415
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

822
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
822

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When the body speaks during wartime: Clinical presentation of older vs. younger adults in psychiatric emergencies during wartime.

The American journal of emergency medicine·2026
Same author

Adapting to the digital age in psychiatry: evaluating change in emergency department nurses and psychiatrists' views toward telepsychiatry for involuntary hospitalization.

Frontiers in digital health·2026
Same author

Multiplexed detection of febrile infections using CARMEN.

Nature communications·2025
Same author

Responsibility of follow-up regarding medical recommendations in primary care and challenging patients: The perspective of doctors, nurses, pharmacists, and administrative staff.

Patient education and counseling·2024
Same author

The impact of new-onset cancer among veterans who are receiving warfarin for atrial fibrillation and venous thromboembolism.

Thrombosis research·2016
Same author

Maternal Phenylketonuria: Long-term Outcomes in Offspring and Post-pregnancy Maternal Characteristics.

JIMD reports·2015
Same journal

Predicting deep venous thrombosis and pulmonary embolism in community patients with superficial venous thrombosis: a model development study.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Transfer of Emicizumab into Breast Milk in Postpartum Acquired Hemophilia A.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Direct oral anticoagulant use and drug-drug interactions in transplant recipients receiving calcineurin inhibitors.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Explaining recurrent thrombotic events and predicting bleeding in critically ill neonates diagnosed with umbilical central venous catheter-related portal vein thrombosis.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

RNA Sequencing Indicates Distinct Platelet Transcriptomic Changes in Immune Thrombocytopenia.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Joint effect of muscle strength and physical inactivity on risk of incident venous thromboembolism: The Tromsø Study.

Journal of thrombosis and haemostasis : JTH·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.2K

Pathways to poor anticoagulation control.

Z Razouki1, A Ozonoff, S Zhao

  • 1Center for Healthcare Organization and Implementation Research, Bedford VA Medical Center, Bedford, MA, USA; Department of Medicine, Section of General Internal Medicine, Boston University School of Medicine, Boston, MA, USA.

Journal of Thrombosis and Haemostasis : JTH
|February 20, 2014
PubMed
Summary
This summary is machine-generated.

Patient factors predict different warfarin anticoagulation control patterns. Alcohol abuse, numerous medications, and hospitalizations lead to erratic international normalized ratio (INR) levels, while other conditions cause consistently low INR.

Keywords:
anticoagulantsinternational normalized ratioquality of healthcareveteranswarfarin

More Related Videos

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.6K
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.6K

Related Experiment Videos

Last Updated: May 2, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
23:33

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

84.2K
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

34.6K
In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time
09:19

In Vitro Microfluidic Disease Model to Study Whole Blood-Endothelial Interactions and Blood Clot Dynamics in Real-Time

Published on: May 24, 2020

9.6K

Area of Science:

  • Pharmacology
  • Clinical Medicine
  • Health Services Research

Background:

  • Understanding patient-level factors influencing warfarin anticoagulation control is crucial.
  • Limited knowledge exists on predictors for time spent specifically above or below the therapeutic international normalized ratio (INR) range.

Purpose of the Study:

  • To identify predictors of distinct international normalized ratio (INR) control patterns in warfarin patients.
  • Differentiate between 'erratic' (both above and below target) and unidirectional (predominantly low or high) INR patterns.

Main Methods:

  • Analysis of 103,897 patients on warfarin with a target INR of 2-3.
  • Data collected from 100 Veterans Health Administration sites (Oct 2006 - Sep 2008).
  • Examined patient demographics, comorbidities, and clinical data as predictors of time above and below INR target.

Main Results:

  • Alcohol abuse, polypharmacy (>16 medications), and multiple hospitalizations predicted 'erratic' INR control (more time both above and below target).
  • Cancer, non-alcohol drug abuse, dementia, and bipolar disorder were associated with more time below target and less time above target.

Conclusions:

  • Distinct patient-level factors are associated with unidirectional below-target INR control versus 'erratic' control.
  • Tailored interventions are required to address the specific pathways leading to poor anticoagulation control.