Related Experiment Video
Updated: May 2, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
Published on: February 9, 2011
[Cluster outbreak of MRSA in the community; recognition and approach]
C F H Stijn Raven1, Peter van Wijngaarden, Gonny Moen
1GGD West-Brabant, Afd. Infectieziektebestrijding, Breda.
Background:
Community-acquired infection with methicillin-resistant Staphylococcus aureus (CA-MRSA) mainly affects healthy young people, without health-care related risk factors for MRSA. Patients often present with skin and soft-tissue infections.
Case Description:
An 18-year-old woman presented at the casualty department with recurrent purulent skin infections. She proved to be MRSA-positive. Within 6 months, 2 people around her also developed an MRSA infection. Culture showed CA-MRSA, with an identical strain (spa type: t008). Additional screening within her immediate circle identified 4 carriers, 2 of whom had corresponding skin infections.
Conclusion:
Cluster outbreaks of CA-MRSA require a coordinated approach from both the treating physician and the public health services. The choice of additional investigation among the circle of contacts was the determining factor in breaking the cycle of transmission and reinfection within this cluster.
Insights
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) can spread within close contacts, causing skin infections. Prompt investigation of a patient's circle is key to stopping CA-MRSA transmission and reinfection clusters.
Area of Science:
- Infectious Diseases
- Public Health
- Microbiology
Background:
- Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) primarily affects healthy young individuals.
- CA-MRSA infections commonly manifest as skin and soft-tissue infections.
- These infections occur in individuals without typical healthcare-associated risk factors for MRSA.
Observation:
- A case study involved an 18-year-old woman with recurrent skin infections who tested positive for MRSA.
- Within six months, two close contacts also developed MRSA infections caused by an identical CA-MRSA strain (spa type: t008).
- Screening identified four carriers within her social circle, two of whom had active skin infections.
Findings:
- The study identified a CA-MRSA cluster outbreak originating from a single index case.
- Molecular analysis confirmed an identical MRSA strain (spa type: t008) in all affected individuals and carriers.
- Contact tracing and screening were crucial in identifying transmission pathways.
Implications:
- Coordinated management between healthcare providers and public health services is essential for controlling CA-MRSA outbreaks.
- Targeted investigation of close contacts is critical for interrupting transmission cycles.
- Early identification and intervention in contact circles can prevent further spread and reinfection.
Related Concept Videos
Clinical Significance of Antibiotic Resistance
Staphylococcal Skin Infections
Mechanism of Antibiotic Resistance in MRSA
Steps in Outbreak Investigation
Investigation of Disease Outbreaks
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...

