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Thai (delta beta)0-thalassemia and its interaction with gamma-thalassemia
R J Trent1, L Svirklys, P Jones
1Molecular Biology Laboratory, University of Sydney, NSW, Australia.
Hemoglobin
|January 1, 1988
Abstract:
A variant of Southern Italian (delta beta)0-thalassemia is described in a women of Thai origin. The 3' breakpoint in Thai (delta beta)0-thalassemia is located about 1 kb upstream to that in Southern Italian (delta beta)0-thalassemia and produces a smaller deletion of approximately equal to 12.5 kb. Hematological phenotype, particularly Hb F output, is similar to that found in G gamma A gamma(delta beta)0-thalassemia despite the presence of a coexistent gamma-thalassemia effect.