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The promise of translational and personalised approaches for paediatric obstructive sleep apnoea: an 'Omics'

Hui-Leng Tan1, Leila Kheirandish-Gozal, David Gozal

  • 1Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, , London, UK.

Thorax
|February 20, 2014
PubMed

Insights

Obstructive sleep apnoea (OSA) causes widespread harm through inflammation and oxidative stress. Advanced

Area of Science:

  • Sleep Medicine
  • Genetics
  • Molecular Biology

Background:

  • Obstructive sleep apnoea (OSA) is linked to cardiovascular, metabolic, and neurocognitive issues.
  • Pathophysiological mechanisms of OSA and its varied clinical presentations remain unclear.
  • Inflammatory cascades and oxidative stress are suspected mediators of OSA-related damage.

Purpose of the Study:

  • To review recent advances in understanding genotype-phenotype interactions in OSA.
  • To explore the role of epigenetics, genomics, and proteomics in OSA.
  • To highlight how 'Omics' approaches can advance personalized diagnosis and management of OSA.

Main Methods:

  • Review of current literature on OSA genetics and molecular mechanisms.
  • Synthesis of findings on genotype-phenotype correlations.
  • Discussion of 'Omics' technologies (genomics, proteomics, epigenetics) in sleep medicine.

Main Results:

  • Emerging evidence links specific genetic profiles to OSA phenotypes and end-organ damage.
  • Epigenetic modifications may influence OSA susceptibility and severity.
  • 'Omics' data provide a deeper understanding of OSA's molecular underpinnings.

Conclusions:

  • 'Omics' technologies offer transformative potential for OSA research and clinical practice.
  • Understanding genetic and molecular factors is crucial for personalized OSA management.
  • Further research into genotype-phenotype interactions will elucidate OSA's complex pathophysiology.

Keywords:
Sleep apnoea

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