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Related Experiment Video

Updated: May 2, 2026

Recording and Analysis of Circadian Rhythms in Running-wheel Activity in Rodents
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PERIOD1 coordinates hippocampal rhythms and memory processing with daytime.

Oliver Rawashdeh1, Antje Jilg, Peter Jedlicka

  • 1Institute of Cellular and Molecular Anatomy, Dr. Senckenbergische Anatomie, Goethe-University, Theodor-Stern-Kai 7, Frankfurt, Germany.

Hippocampus
|February 20, 2014
PubMed
Summary
This summary is machine-generated.

The clock gene PER1 is crucial for daily memory performance variations in mice. It regulates memory molecule CREB phosphorylation and chromatin remodeling, impacting spatial memory. This reveals PER1's role in time-dependent memory.

Keywords:
CREBLTPchromatincircadianclock geneepigeneticslearning

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Area of Science:

  • Neuroscience
  • Chronobiology
  • Molecular Biology

Background:

  • Time of day significantly influences memory processing across species.
  • Mechanisms behind these temporal memory variations, particularly the role of clock genes, remain unclear.

Purpose of the Study:

  • To investigate the role of the clock gene Period1 (Per1) in regulating daily rhythms of memory-related molecular processes in the mouse hippocampus.
  • To elucidate how Per1 influences CREB phosphorylation, chromatin remodeling, and subsequent memory performance.

Main Methods:

  • Compared hippocampal molecular dynamics in wildtype (WT) mice and Per1-deficient (Per1(-/-)) mice.
  • Analyzed daytime-dependent phosphorylation of CREB and histone modifications.
  • Measured in vivo long-term potentiation (LTP) and spatial working memory performance.

Main Results:

  • Per1 deficiency abolished circadian rhythms of CREB phosphorylation in the hippocampus.
  • Day/night rhythms of histone modifications were significantly perturbed in Per1(-/-) mice.
  • Absence of Per1 altered LTP, gene expression, and eliminated daytime differences in spatial working memory.

Conclusions:

  • The clock gene PER1 is essential for the daily rhythmicity of memory performance.
  • PER1 likely gates CREB signaling and couples it to chromatin remodeling to shape time-dependent memory.
  • This study provides a molecular framework for understanding how circadian rhythms impact cognitive functions like memory.