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Updated: May 2, 2026
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Published on: March 7, 2019
Amyloid-Beta related angiitis of the central nervous system: case report and topic review
Amre Nouh1, Ewa Borys2, Angelica K Gierut3
1Department of Neurology, Stritch School of Medicine, Loyola University Chicago , Maywood, IL , USA.
Abstract:
Amyloid-beta related angiitis (ABRA) of the central nervous system (CNS) is a rare disorder with overlapping features of primary angiitis of the CNS and cerebral amyloid angiopathy. We evaluated a 74-year-old man with intermittent left sided weakness and MRI findings of leptomeningeal enhancement, vasogenic edema, and subcortical white matter disease proven to have ABRA. We discuss clinicopathological features and review the topic of ABRA.
Insights
Amyloid-beta related angiitis (ABRA) is a rare central nervous system (CNS) disorder. This case study details a patient diagnosed with ABRA, highlighting its overlapping features with other CNS conditions.
Area of Science:
- Neurology
- Neuroimmunology
- Vascular Neurology
Background:
- Amyloid-beta related angiitis (ABRA) is a rare neurological disorder.
- It presents with overlapping clinical and radiological features of primary angiitis of the CNS and cerebral amyloid angiopathy.
- ABRA affects the central nervous system (CNS).
Purpose of the Study:
- To describe a case of ABRA in a 74-year-old male patient.
- To discuss the clinicopathological features of ABRA.
- To review the existing literature on ABRA.
Main Methods:
- Case report of a 74-year-old male with intermittent left-sided weakness.
- Magnetic Resonance Imaging (MRI) findings including leptomeningeal enhancement, vasogenic edema, and subcortical white matter disease.
- Pathological confirmation of ABRA.
Main Results:
- The patient presented with neurological deficits and characteristic MRI findings.
- Diagnosis of ABRA was confirmed.
- The case illustrates the complex presentation of ABRA.
Conclusions:
- ABRA is a rare CNS vasculopathy with features mimicking other conditions.
- Early recognition and diagnosis are crucial for appropriate management.
- Further research is needed to understand ABRA pathogenesis and treatment.
