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The impact of Vitamin D Replacement on Glucose Metabolism
Parildar H1, Cigerli O2, Unal DA3
1Parildar H, Department of Family Medicine, Baskent University, Turkey.
Objective:
We investigated the impact of vitamin D supplementation on glucose metabolism in Vitamin D-deficient patients with prediabetes.
Methods:
A total of 66 subjects with the mean ages 52.2±9.9 years were included in this prospective and a 6-month follow-up study between 2008-2010. Vitamin D deficient patients (<25ng/ml) were supplemented with oral Vitamin D.
Results:
Vitamin D deficiency (<25ng/ml) was found in 93.9% of the patients. Post replacement Vitamin D levels increased significantly and insulin, HbA1c, and HOMA-IR decreased significantly following Vitamin D replacement. Conclusion : We found Vitamin D deficiency was very common in our study population. In Vitamin D deficient patients, supplementation treatment improved insulin resistance and glycemic parameters. Vitamin D replacement may be a promising intervention for the primary prevention of insulin resistance syndromes.
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