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Malignant mesothelioma.

Ishtiaq Ahmed1, Salman Ahmed Tipu2, Sundas Ishtiaq3

  • 1Prof. Dr. Ishtiaq Ahmed, Professor, Department of Surgery, Al-Nafees Medical College, Islamabad, Pakistan.

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|February 20, 2014
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Summary

Malignant mesothelioma (MM) is a rare, aggressive cancer linked to asbestos exposure. Early diagnosis is crucial, as surgical resection offers the best survival outcomes for this challenging disease.

Keywords:
AsbestosMalignant MesotheliomaPeritoneumSurgery

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Area of Science:

  • Oncology
  • Pathology

Background:

  • Malignant Mesothelioma (MM) is a rare, aggressive neoplasm affecting mesothelial surfaces like the pleura and peritoneum.
  • Its etiology is strongly linked to asbestos exposure, a principal carcinogen from industrial pollutants.
  • The natural history of MM is not well understood, contributing to diagnostic delays.

Purpose of the Study:

  • To review the etiology, diagnosis, and treatment of Malignant Mesothelioma.
  • To highlight the importance of early detection and the role of surgery in improving patient survival.

Main Methods:

  • Data were collected from case reports, cross-sectional studies, open-label studies, and phase-II trials.
  • Literature search conducted using online resources from the American College of Surgeons, Medline, NCBI, and Medscape.

Main Results:

  • Malignant Mesothelioma (MM) is a rare but aggressive tumor with increased incidence.
  • Diagnosis is often delayed due to long latent periods and nonspecific symptoms.
  • Radical surgical resection is the preferred treatment, significantly improving median and 5-year survival rates.

Conclusions:

  • Malignant Mesothelioma (MM) remains a rare, aggressive, and often fatal tumor.
  • A high index of suspicion is necessary for timely diagnosis due to frequent delays.
  • Surgical intervention offers the most promising survival benefit for patients with MM.