Association between CC10 +38A/G polymorphism and asthma risk: A meta-analysis

Area of Science:

• Genetics
• Pulmonology
• Epidemiology

Background:

• Inconsistent results exist regarding the association between Clara cell 10-kDa protein (CC10) +38A/G polymorphism and asthma susceptibility.
• Previous studies have yielded inconclusive findings on this genetic link.

Purpose of the Study:

• To conduct a meta-analysis assessing the association between CC10 +38A/G polymorphism and asthma risk.
• To consolidate existing evidence and provide a more definitive conclusion on the genetic predisposition to asthma.

Main Methods:

• A systematic literature search identified relevant case-control studies published between January 1998 and March 2013.
• Pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated using fixed and random-effects models.
• The association was evaluated across dominant, recessive, additive, and codominant genetic models.

Main Results:

• The meta-analysis included 10 studies with 1529 asthma cases and 2399 controls.
• A significant association was found between CC10 +38A/G polymorphism and elevated asthma risk in the dominant model (OR = 1.62; 95% CI, 1.23-2.12; P = 0.0005).
• Subgroup analyses revealed significant associations in Asian and Caucasian populations, with other genetic models also supporting this link.

Conclusions:

• The CC10 +38A/G polymorphism is suggested to confer an increased risk of asthma.
• This genetic variant represents a potential factor in asthma susceptibility across different ethnic groups.