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Updated: May 2, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Early life course risk factors for childhood obesity: the IDEFICS case-control study
Karin Bammann1, Jenny Peplies2, Stefaan De Henauw3
1Institute for Public Health and Nursing Research (IPP), University of Bremen, Bremen, Germany ; BIPS Institute for Prevention Research and Epidemiology, Bremen, Germany.
Insights
Parental body mass index (BMI) and excessive gestational weight gain are key risk factors for childhood obesity. Prevention strategies should involve adults and focus on monitoring maternal weight during pregnancy.
Area of Science:
- Pediatric Endocrinology
- Public Health Nutrition
- Epidemiology
Background:
- Childhood obesity is a growing concern, with the early life course considered a critical developmental period.
- The interplay of various pre-, peri-, and postpartum factors contributing to childhood obesity requires further investigation.
Purpose of the Study:
- To examine pre-, peri-, and postpartum risk factors associated with childhood obesity.
- To identify significant predictors of obesity in children aged 2 to 9 years.
Main Methods:
- A case-control study nested within the IDEFICS population-based intervention study.
- Involved 1,024 matched case-control pairs across 8 European countries.
- Utilized conditional logistic regression to identify risk factors for childhood obesity.
Main Results:
- Gestational weight gain, smoking during pregnancy, Caesarian section, and breastfeeding duration showed associations with obesity risk.
- Maternal and paternal BMI were identified as the strongest risk factors, confounding other associations.
- After adjusting for parental BMI and education, only gestational weight gain remained statistically significant.
Conclusions:
- Parental BMI and gestational weight gain are critical risk factors for childhood obesity.
- Prevention efforts should target both children and adults, with a focus on maternal weight monitoring.
- Early intervention strategies are crucial for mitigating childhood obesity risks.
Background:
The early life course is assumed to be a critical phase for childhood obesity; however the significance of single factors and their interplay is not well studied in childhood populations.
Objectives:
The investigation of pre-, peri- and postpartum risk factors on the risk of obesity at age 2 to 9.
Methods:
A case-control study with 1,024 1:1-matched case-control pairs was nested in the baseline survey (09/2007-05/2008) of the IDEFICS study, a population-based intervention study on childhood obesity carried out in 8 European countries in pre- and primary school settings. Conditional logistic regression was used for identification of risk factors.
Results:
For many of the investigated risk factors, we found a raw effect in our study. In multivariate models, we could establish an effect for gestational weight gain (adjusted OR = 1.02; 95%CI 1.00-1.04), smoking during pregnancy (adjusted OR = 1.48; 95%CI 1.08-2.01), Caesarian section (adjusted OR = 1.38; 95%CI 1.10-1.74), and breastfeeding 4 to 11 months (adjusted OR = 0.77; 95%CI 0.62-0.96). Birth weight was related to lean mass rather than to fat mass, the effect of smoking was found only in boys, but not in girls. After additional adjustment for parental BMI and parental educational status, only gestational weight gain remained statistically significant. Both, maternal as well as paternal BMI were the strongest risk factors in our study, and they confounded several of the investigated associations.
Conclusions:
Key risk factors of childhood obesity in our study are parental BMI and gestational weight gain; consequently prevention approaches should target not only children but also adults. The monitoring of gestational weight seems to be of particular importance for early prevention of childhood obesity.
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