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Treg cells: a potential regulator for IL-22 expression?

Shuman Lin1, Xuyan Yang2, Dian Liang1

  • 1Medical College at Sun Yat‑Sen University Guangzhou, 510008, P. R. China.

International Journal of Clinical and Experimental Pathology
|February 20, 2014
PubMed

Inteleurkin-22 (IL-22) is a IL-10 family cytokine member and is mainly produced by innate lymphoid cells (ILCs), Th17 cells, and Th22 cells. Previous studies have indicated that IL-23 and several transcription factors, including STAT3, RORγt, and the AhR are important stimulus. Recently, there is emerging evidence that Tregs can regulate IL-22 expression. In the review, we discuss the updated advancement on Tregs function and its regulatory role on IL-22 expression.

Keywords:
Interleukin-22T helper cellsinnate immune cellsregulatory (Treg) cells

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