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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Related Experiment Video

Updated: May 2, 2026

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
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Treg cells: a potential regulator for IL-22 expression?

Shuman Lin1, Xuyan Yang2, Dian Liang1

  • 1Medical College at Sun Yat‑Sen University Guangzhou, 510008, P. R. China.

International Journal of Clinical and Experimental Pathology
|February 20, 2014
PubMed
Summary
This summary is machine-generated.

Regulatory T cells (Tregs) are increasingly recognized for their role in controlling Interleukin-22 (IL-22) expression. This review highlights recent advancements in understanding Treg function and their impact on IL-22 production.

Keywords:
Interleukin-22T helper cellsinnate immune cellsregulatory (Treg) cells

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Area of Science:

  • Immunology
  • Cytokine Biology
  • Cellular Regulation

Background:

  • Interleukin-22 (IL-22) is a cytokine in the IL-10 family, primarily produced by innate lymphoid cells (ILCs), Th17, and Th22 cells.
  • IL-23 and transcription factors like STAT3, RORγt, and AhR are known stimuli for IL-22 production.
  • Emerging evidence suggests a regulatory role for regulatory T cells (Tregs) in controlling IL-22 expression.

Purpose of the Study:

  • To review and discuss the latest advancements in understanding the function of regulatory T cells (Tregs).
  • To elucidate the specific regulatory mechanisms by which Tregs influence Interleukin-22 (IL-22) expression.
  • To consolidate current knowledge on the interplay between Tregs and IL-22 in immune responses.

Main Methods:

  • Literature review of recent studies on Treg function.
  • Analysis of research on transcription factors and signaling pathways involved in IL-22 regulation.
  • Synthesis of data on the interaction between Tregs and IL-22-producing cells.

Main Results:

  • Tregs exhibit diverse functions beyond immune suppression, including modulation of cytokine production.
  • Specific Treg subsets and their secreted factors can directly or indirectly impact IL-22 levels.
  • The interaction between Tregs and IL-22 is crucial for maintaining tissue homeostasis and immune surveillance.

Conclusions:

  • Regulatory T cells (Tregs) play a significant, previously underappreciated role in modulating Interleukin-22 (IL-22) expression.
  • Further research into Treg-IL-22 interactions can reveal novel therapeutic targets for inflammatory and autoimmune diseases.
  • Understanding this regulatory axis is key to comprehending complex immune system dynamics.