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Vitamins01:30

Vitamins

2.7K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

8.1K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.1K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.1K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.7K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.7K
Connective Tissue Cell Types01:22

Connective Tissue Cell Types

3.4K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.4K
Minerals01:26

Minerals

1.7K
Minerals are essential nutrients that the human body needs in small amounts to work properly. They play a vital role in many bodily functions, such as building strong bones and transmitting nerve impulses. Some minerals are needed for hormone production or to maintain a normal heartbeat. Major minerals include calcium, phosphorus, potassium, sulfur, sodium, chlorine, and magnesium, while trace minerals include iron, manganese, copper, iodine, zinc, cobalt, fluoride, and selenium.
 
Major...
1.7K

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Related Experiment Video

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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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Mining MEDLINE for problems associated with vitamin D.

Dina Demner-Fushman1, James G Mork1, Alan R Aronson1

  • 1Lister Hill National Center for Biomedical Communications, U.S. National Library of Medicine, National Institutes of Health, DHHS, Bethesda, MD.

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PubMed
Summary
This summary is machine-generated.

This study introduces a two-step method for creating biomedical summaries using MEDLINE/PubMed searches and Natural Language Processing (NLP). MeSH-based filtering aids overview generation, though relation extraction needs improvement for comprehensive health indicator analysis.

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Area of Science:

  • Biomedical Informatics
  • Natural Language Processing
  • Medical Literature Analysis

Background:

  • Generating comprehensive summaries of complex biomedical topics is challenging.
  • Existing methods may not efficiently capture key relationships within large literature datasets.
  • Automated approaches are needed to synthesize information from sources like MEDLINE/PubMed.

Purpose of the Study:

  • To develop and evaluate a two-step approach for generating abstractive overviews of biomedical topics.
  • To assess the utility of MeSH-based filtering and NLP-driven relation extraction in this process.
  • To validate the approach using a case study on Vitamin D's role in human health.

Main Methods:

  • A sensitivity-maximizing search of MEDLINE/PubMed.
  • MeSH (Medical Subject Headings)-based filtering of search results.
  • Natural Language Processing (NLP) for extracting relations between biomedical entities.
  • Evaluation using disorders listed in the IOM report on Vitamin D as a reference standard.

Main Results:

  • MeSH-based aggregation and filtering proved to be a useful and straightforward step in generating abstractive overviews.
  • Relation extraction achieved high performance with 83.6% recall and 92.8% precision.
  • However, only 50% of the identified health indicators (disorders) were involved in the extracted relations.

Conclusions:

  • MeSH-based filtering is an effective component for creating biomedical summaries.
  • While relation extraction is precise, its coverage of relevant health indicators requires further enhancement.
  • The presented approach offers a foundation for improved automated biomedical literature summarization.