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Root maturation and dentin-pulp response to enamel matrix derivative in pulpotomized permanent teeth
Sherif S Darwish1, Shadia H Abd El Meguid2, Nadia A Wahba3
1Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Pharos University, Egypt.
Journal of Tissue Engineering
|February 20, 2014
Summary
Enamel matrix derivative (Emdogain) did not regenerate the dentin-pulp complex in immature dog teeth, unlike calcium hydroxide. Emdogain showed potential for periodontium regeneration but led to pulp inflammation and degeneration.
Area of Science:
- Endodontics
- Regenerative Dentistry
- Dental Histology
Background:
- Pulpotomy success in young permanent teeth relies on appropriate dressing materials.
- Evaluating regenerative potential of pulp capping agents is crucial for immature permanent dentition.
Purpose of the Study:
- To compare the histological and histomorphometric effects of enamel matrix derivative (Emdogain) versus calcium hydroxide as pulp dressings in immature permanent dog teeth.
- To assess the regenerative capacity of Emdogain on the dentin-pulp complex and periodontium.
Main Methods:
- Immature permanent dog teeth underwent pulpotomy and were dressed with either Emdogain or calcium hydroxide.
- Histological and histomorphometric analyses were performed at various time points.
- Evaluated dentin bridge formation, pulp inflammation, and root apex maturation.
Main Results:
- Both Emdogain and calcium hydroxide initially induced dentin-like tissue formation.
- Calcium hydroxide promoted a persistent and thickening dentin bridge.
- Emdogain treatment resulted in disintegration of the dentin bridge, progressive pulp inflammation, and degeneration.
- Emdogain promoted root apex maturation and periodontal regeneration.
Conclusions:
- Emdogain is not suitable for dentin-pulp complex regeneration in immature permanent teeth.
- Emdogain may be a viable option for periodontal regeneration in young permanent dentition.
- Calcium hydroxide remains a suitable material for pulpotomy in immature permanent teeth, promoting dentin bridge formation.
Keywords:
Pulpotomycalcium hydroxidedentin bridge and histomorphometric analysisenamel matrix derivativeMore Related Videos
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