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Updated: May 2, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Balanced chromosomal rearrangement in recurrent spontaneous abortions: a case report
Ahmadreza Zarifian1, Zeinab Farhoodi1, Roya Amel1
1Student Research Assembly, Mashhad University of Medical Sciences, Iran.
Abstract:
One of the major causes of spontaneous abortion before the fourth month of pregnancy is chromosomal abnormalities. We report an unusual case of a familial balanced chromosomal translocation in a consanguineous couple who experienced 4 spontaneous abortions. Chromosomal studies were performed on the basis of G-banding technique at high resolution and revealed 46, XX, t (16; 6) (p12; q26) and 46, XY, t (16; 6) (p12; q26) in both partners, which induced such pregnancy complications. Chromosomal balanced translocation is one of the most common causes of recurrent spontaneous abortions (RSA). In such cases prenatal diagnosis (PND) during the 16(th) week of gestation is strongly recommended.
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