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Takotsubo cardiomyopathy: a review
Mahdi Veillet-Chowdhury1, Syed Fahad Hassan, Kathleen Stergiopoulos
1Division of Cardiovascular Disease, Department of Medicine, Stony Brook University Medical Center , Stony Brook, NY , USA.
Acute Cardiac Care
|February 21, 2014
Summary
Takotsubo cardiomyopathy, a stress-induced heart condition, affects postmenopausal women and causes temporary left ventricular dysfunction. Its exact cause, possibly catecholamine excess, requires further study.
Area of Science:
- Cardiology
- Neurology
- Endocrinology
Background:
- Takotsubo cardiomyopathy (TTC) is a stress-related heart condition.
- It presents with transient left ventricular dysfunction in the absence of coronary artery disease.
- Commonly observed in postmenopausal women, it follows acute stressors like stroke or trauma.
Purpose of the Study:
- To summarize the characteristics and potential pathophysiology of Takotsubo cardiomyopathy.
- To highlight the need for further research into its incidence, clinical course, and prognosis.
Main Methods:
- Review of existing literature on Takotsubo cardiomyopathy.
- Analysis of clinical presentations and potential triggers.
Main Results:
- TTC is triggered by acute mental or physical stress, including subarachnoid hemorrhage, stroke, head trauma, or pheochromocytoma crisis.
- Characterized by apical and/or midventricular systolic dysfunction.
- Most prevalent in postmenopausal women.
Conclusions:
- The pathophysiology may involve catecholamine excess and vasospasm.
- Further research, potentially through an international registry, is needed to fully understand TTC's incidence, pathophysiology, clinical course, and prognosis.
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