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Psychosurgery01:30

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Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Related Experiment Video

Updated: May 2, 2026

Minimally Invasive Thumb-sized Pterional Craniotomy for Surgical Clip Ligation of Unruptured Anterior Circulation Aneurysms
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Neurosurgery in octogenarians.

Matthew G Stovell1, Michael D Jenkinson

  • 1The Walton Centre for Neurology and Neurosurgery , Lower Lane, Fazakerley, Liverpool , UK.

British Journal of Neurosurgery
|February 21, 2014
PubMed
Summary

Neurosurgery for octogenarians (patients over 80) shows a higher risk and mortality, especially for emergency procedures. Careful patient selection and enhanced peri-operative care are crucial for this aging population.

Area of Science:

  • Neurosurgery
  • Geriatric Medicine
  • Surgical Outcomes

Background:

  • The global population is aging, leading to increased demand for neurosurgical services in elderly patients.
  • Outcomes and benefits of neurosurgical interventions in octogenarians remain unclear.
  • Previous reports indicate extreme age is an independent risk factor in surgical care.

Purpose of the Study:

  • To evaluate the outcomes of neurosurgical interventions in octogenarian patients.
  • To identify specific risks and benefits associated with neurosurgery in this age group.
  • To inform clinical decision-making for elderly patients undergoing neurosurgical procedures.

Main Methods:

  • Retrospective case review of 134 octogenarian admissions to a regional neurosurgical unit (2010).
Keywords:
age and outcomecomplicationselderlyneurosurgeryoctogenariansoutcome

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  • Analysis of admission pathology, comorbidities, surgical delays, length of stay, discharge destination, functional outcomes, and mortality.
  • Comparison of outcomes between elective and emergency neurosurgical admissions.

    • Main Results:

    • Elective admissions (49) were primarily for degenerative spine (51%) and functional/pain disorders (20%).
    • Emergency admissions (81) were predominantly for cranial trauma (55%).
    • Peri-operative mortality was 0% for elective and 10.4% for emergency cases; good outcomes were observed in 62% for trauma and 69% for degenerative spine.

    Conclusions:

    • Neurosurgery in octogenarians carries a higher complication rate and 30-day mortality compared to younger patients.
    • Careful patient selection is paramount for successful neurosurgical outcomes in the octogenarian population.
    • Enhanced peri-operative care is essential to mitigate risks in elderly patients undergoing neurosurgery.