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Serum S100B level increases after running but not cycling exercise.

Cintia Mussi Alvim Stocchero1, Jean Pierre Oses, Giovani Santos Cunha

  • 1a Federal Institute of Education, Science and Technology of Rio Grande do Sul, Porto Alegre RS, Brazil.

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquee, Nutrition Et Metabolisme
|February 21, 2014
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Summary

Running exercise significantly elevates serum S100B protein and muscle damage markers compared to cycling. S100B shows potential as an acute biomarker for running-induced muscle damage.

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Area of Science:

  • Exercise Physiology
  • Biochemistry
  • Sports Medicine

Background:

  • S100B protein is expressed in skeletal muscle, but its role in exercise-induced muscle damage is not well-established.
  • Previous research has not linked serum S100B levels to skeletal muscle damage markers following exercise.

Purpose of the Study:

  • To investigate the impact of running versus cycling on serum S100B levels and muscle damage markers (creatine kinase, aspartate aminotransferase, myoglobin).
  • To explore the relationship between serum S100B and muscle damage markers after different exercise modalities.

Main Methods:

  • Cross-sectional study involving 13 male triathletes performing submaximal running and cycling protocols at anaerobic threshold intensity.
  • Blood samples collected pre-exercise, immediately post-exercise, and 1 hour post-exercise for analysis of S100B, CK, AST, and Mb.
  • Comparison of marker levels between running and cycling, and correlation analysis between S100B and muscle damage markers.

Main Results:

  • Running exercise led to significant increases in serum S100B, CK, AST, and Mb levels compared to pre-exercise values.
  • Post-exercise serum levels of S100B, CK, AST, and Mb were significantly higher after running than after cycling.
  • In the running group, the area under the curve for serum S100B positively correlated with the area under the curve for CK and Mb.

Conclusions:

  • Intense running exercise, unlike cycling, acutely increases serum S100B levels in parallel with markers of skeletal muscle damage.
  • Serum S100B may serve as a valuable acute biomarker for detecting muscle damage induced by running exercise.