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Prognostic factors in women with synchronous endometrial and ovarian cancers
Taejong Song1, Seok Ju Seong, Duk-Soo Bae
1*Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University; †Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine; ‡Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul; §Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam; ∥Department of Obstetrics and Gynecology, Seoul St Mary's Hospital, Catholic University of Korea, Seoul; ¶Gynecologic Cancer Branch and Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang; and #Department of Obstetrics and Gynecology, SMG-SNU Boramae Medical Center, Seoul, Republic of Korea.
Objective:
The purpose of this study was to determine the prognostic factors in women with synchronous endometrial and ovarian cancers.
Methods:
Medical records of 3240 patients with endometrial cancer who had undergone primary surgery were collected from 7 institutions and were retrospectively reviewed. The progression-free survival (PFS) and overall survival (OS) curves and rates were calculated using the Kaplan-Meier method. Multivariate analysis to determine independent prognostic factors was performed using the Cox regression model.
Results:
The incidence of synchronous endometrial/ovarian cancer was 3.8% (123/3240 women). During the median follow-up period of 66 months, 33.3% and 26.1% of women developed recurrences and reported cancer-related deaths. The 5-year PFS and 5-year OS for all 123 women were 66.9% and 80.0%, respectively. In multivariate analysis, pretreatment CA-125 and tumor stage of the ovary showed prognostic significance about PFS (P = 0.043 and P = 0.027) and OS (P = 0.047 and P = 0.031), respectively.
Conclusions:
Pretreatment CA-125 and tumor stage of the ovary were independent prognostic factors for recurrence and survival.
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