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Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

S C Mack1, H Witt2, R M Piro3

  • 11] Developmental & Stem Cell Biology Program, Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada [2] Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada [3] Division of Neurosurgery, University of Toronto, Toronto, Ontario M5S 1A8, Canada [4].

Nature
|February 21, 2014
PubMed
Summary

Hindbrain ependymomas, a common childhood brain tumor, show few genetic mutations but exhibit epigenetic changes. Targeting these epigenetic alterations offers a promising new therapeutic strategy for this malignancy.

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