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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

1.4K
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Updated: May 2, 2026

In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients
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In Vitro and In Vivo Assessment of T, B and Myeloid Cells Suppressive Activity and Humoral Responses from Transplant Recipients

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Treating the donor.

Dermot W McKeown1, Jonathan Ball

  • 1aScottish Liver Transplant Unit, Edinburgh Royal Infirmary, Edinburgh bGeneral and Neurointensive Care, St George's Hospital and Medical School, London, UK.

Current Opinion in Organ Transplantation
|February 21, 2014
PubMed
Summary
This summary is machine-generated.

Optimizing care for brain-dead organ donors (DBD) is crucial for increasing organ availability. Evidence-based critical care and early identification of potential donors lead to more transplantable organs.

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Area of Science:

  • Critical care medicine
  • Transplantation science
  • Organ donation research

Background:

  • Increasing organ demand necessitates maximizing organ donation potential.
  • The donor population is aging with increased comorbidities.
  • Optimal management of donors after brain death (DBD) is vital for transplanting more organs per donor.

Purpose of the Study:

  • To review evidence-based drugs and techniques for optimizing donor management.
  • To define best practices for critical care in brain-dead organ donors.
  • To reassess the efficacy of previously recommended therapies.

Main Methods:

  • Review of current critical care practices for brain-dead donors.
  • Analysis of outcomes associated with specific supportive therapies.
  • Evaluation of emerging extracorporeal support techniques.

Main Results:

  • Targeted supportive therapy by experienced specialists improves donation outcomes.
  • Prolonged (>24h) ex-vivo organ conditioning shows significant benefits.
  • Extracorporeal support may identify new donor sources in non-responders.

Conclusions:

  • Early identification of potential DBD and best practice critical care increase transplantable organs.
  • Defined treatment goals are associated with better organ yield.
  • International efforts are underway to address challenges in donor management research.