Two offset printing workers with cholangiocarcinoma
1Department of Management of Occupational Safety and Health, University of Occupational and Environmental Health.
Journal of Occupational Health
|February 21, 2014
Summary
Offset printing involves exposure to chemicals like 1,2-dichloropropane (1,2-DCP) and dichloromethane (DCM), which are linked to cholangiocarcinoma. Occupational history is crucial for diagnosing this cancer in printing industry workers.
Area of Science:
- Occupational Medicine
- Hepatobiliary Surgery
- Toxicology
Background:
- The association between 1,2-dichloropropane (1,2-DCP) and dichloromethane (DCM) and cholangiocarcinoma was previously unknown.
- A prior report identified 11 cholangiocarcinoma cases linked to these chemicals in an offset proof-printing company.
Observation:
- This study details two additional cholangiocarcinoma cases in workers from different offset printing companies.
- Case 1 involved 11 years of 1,2-DCP exposure (72–5,200 ppm) in proof-printing.
- Case 2 involved 11 years of DCM exposure (240–6,100 ppm) and 1,1,1-trichloroethane in general offset printing.
Findings:
- Both patients developed cholangiocarcinoma after prolonged occupational exposure to 1,2-DCP or DCM.
- The identified exposure levels suggest a significant risk associated with these printing industry solvents.
Implications:
- The offset printing process is a potential cause of cholangiocarcinoma.
- Thorough occupational history assessment is vital for patients diagnosed with cholangiocarcinoma.
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