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Circulating natriuretic peptide concentrations reflect changes in insulin sensitivity over time in the Diabetes
Geoffrey A Walford1, Yong Ma, Costas A Christophi
1Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA.
Diabetologia
|February 21, 2014
Summary
N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are linked to insulin sensitivity in individuals at risk for type 2 diabetes. This association remains significant even after accounting for body fat and intervention type in the Diabetes Prevention Program (DPP).
Area of Science:
- Cardiovascular Biomarkers
- Metabolic Health
- Diabetes Prevention
Background:
- N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a marker associated with cardiovascular and metabolic conditions.
- Insulin sensitivity plays a crucial role in glucose metabolism and is often impaired in individuals at risk for type 2 diabetes.
- Adiposity measures like BMI and waist circumference are known risk factors for type 2 diabetes and insulin resistance.
Purpose of the Study:
- To investigate the relationship between adiposity, insulin sensitivity, and NT-proBNP levels within the context of the Diabetes Prevention Program (DPP).
- To determine if this relationship changes over time with interventions aimed at preventing type 2 diabetes.
Main Methods:
- Analysis of stored samples from the completed DPP clinical trial.
- Measurement of body mass index (BMI), waist circumference (WC), insulin sensitivity index (ISI), and NT-proBNP at baseline and 2-year follow-up.
- Comparison of outcomes across placebo, intensive lifestyle intervention, and metformin treatment arms.
Main Results:
- At baseline, NT-proBNP correlated with insulin sensitivity (ISI) and waist circumference (WC), but not BMI.
- After 2 years, BMI and WC decreased, while insulin sensitivity increased in lifestyle and metformin groups.
- Changes in NT-proBNP were positively associated with changes in insulin sensitivity, independent of changes in BMI or WC.
Conclusions:
- Circulating NT-proBNP is associated with insulin sensitivity in individuals at risk for type 2 diabetes.
- This association persists during preventive interventions and is independent of adiposity measures.
- The findings highlight a potential link between natriuretic peptides and metabolic dysfunction relevant to diabetes prevention.
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