Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

28
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
28
The Thyroid Gland01:23

The Thyroid Gland

7.0K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
7.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The utility of parathyroid autofluorescence as an adjunct in thyroid and parathyroid surgery 2023.

Head & neck·2023
Same author

Clinical characteristics, treatment patterns and relapse in patients with clinical stage IS testicular cancer.

World journal of urology·2021
Same author

[Influence of the working model on the education of young urologists : Education through the ages].

Der Urologe. Ausg. A·2021
Same author

[COVID-19 in urology : Influence of the pandemic on telemedicine, education and surgery].

Der Urologe. Ausg. A·2021
Same author

[Surgical treatment of intracaval tumor relapse after radical tumor nephrectomy in locally advanced renal cell carcinoma].

Der Urologe. Ausg. A·2020
Same author

[Targeted molecular therapy and immunotherapy for prostate cancer].

Der Urologe. Ausg. A·2020

Related Experiment Video

Updated: May 2, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.1K

Anaplastic thyroid carcinoma: a 25-year single-institution experience.

A Mohebati1, M Dilorenzo, F Palmer

  • 1Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Annals of Surgical Oncology
|February 21, 2014
PubMed
Summary
This summary is machine-generated.

Anaplastic thyroid carcinoma (ATC) survival is poor, but aggressive treatment improves outcomes. Multimodality therapy including surgery and radiation offers the best chance for patients with limited disease.

More Related Videos

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.6K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

24.0K

Related Experiment Videos

Last Updated: May 2, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.1K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.6K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

24.0K

Area of Science:

  • Oncology
  • Thyroid Cancer Research
  • Surgical Oncology

Background:

  • Anaplastic thyroid carcinoma (ATC) is a rare and aggressive thyroid malignancy.
  • ATC accounts for 1-5% of all thyroid cancers.
  • Limited data exists on prognostic factors and optimal treatment for ATC.

Purpose of the Study:

  • To evaluate prognostic factors, treatment strategies, and patient outcomes in ATC.
  • To identify predictors of survival in ATC patients.
  • To analyze treatment approaches at a single institution.

Main Methods:

  • Retrospective review of 83 ATC patients diagnosed between 1985 and 2010.
  • Analysis of patient, tumor, and treatment characteristics.
  • Kaplan-Meier method for disease-specific survival (DSS) and univariate/multivariate analyses for prognostic factors.

Main Results:

  • Median survival was 8 months, with 1- and 2-year DSS of 33% and 23%, respectively.
  • Younger age, N0 neck, absence of extrathyroidal extension (ETE), gross total resection, and multimodality treatment predicted improved survival.
  • Multivariate analysis identified absence of cETE, gross total resection, and multimodality therapy as significant predictors of better outcomes.

Conclusions:

  • Multimodality treatment, including gross total resection and postoperative radiotherapy, improves local control and DSS in locoregional limited ATC.
  • Aggressive surgical and adjuvant therapies are crucial for improving outcomes in anaplastic thyroid carcinoma.