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Related Experiment Video

Updated: May 2, 2026

Author Spotlight: Assessment of Cardiac Output Calculation by Thermodilution in Pigs for Effective Perfusion Flow During EVLP

Author Spotlight: Assessment of Cardiac Output Calculation by Thermodilution in Pigs for Effective Perfusion Flow During EVLP

Published on: June 28, 2024

Novel continuous capnodynamic method for cardiac output assessment during mechanical ventilation.

C Hällsjö Sander¹, M Hallbäck, M Wallin

¹Department of Anaesthesiology, Surgical Services and Intensive Care Medicine, Karolinska University Hospital, Solna SE-171 76, Sweden.

British Journal of Anaesthesia

|February 21, 2014

Summary

A novel capnodynamic method (COEPBF) for cardiac output (CO) monitoring shows reliable trending abilities, comparable to pulmonary artery catheter (PAC) thermodilution. Further studies are needed to confirm its accuracy in high-risk patients.

Keywords:

carbon dioxide, measurement heart, cardiac output measurement techniques, carbon dioxide measurement techniques, cardiac output measurement techniques, thermodilution

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Evaluation of Capnography Sampling Line Compatibility and Accuracy when Used with a Portable Capnography Monitor

Evaluation of Capnography Sampling Line Compatibility and Accuracy when Used with a Portable Capnography Monitor

Published on: September 29, 2020

Area of Science:

Cardiovascular Physiology
Critical Care Medicine
Medical Monitoring Technology

Background:

Accurate cardiac output (CO) monitoring is crucial in high-risk surgery and critical care.
Pulmonary artery catheters (PAC) are invasive, necessitating minimally invasive CO monitoring alternatives.
Endogenous carbon dioxide measurements offer a potential non-invasive approach via differentiated Fick's principle.

Purpose of the Study:

To validate a novel capnodynamic method (COEPBF) for estimating CO.
To assess COEPBF performance across diverse hemodynamic conditions.
To compare COEPBF accuracy and trending ability against established methods.

Main Methods:

COEPBF was evaluated in 10 pigs under varying hemodynamic states (preload, afterload, CO increase, bleeding).
Pulmonary artery ultrasonic flow probe served as the reference for CO.
CO was also measured using pulmonary artery catheter (PAC) thermodilution (COPAC); data analyzed with Bland-Altman and polar plots.

Main Results:

COEPBF demonstrated agreement with COPAC, with slight overestimation (bias 0.2 L/min).
Overall percentage error was 47% for COEPBF and 49% for COPAC.
Trending concordance was high: 97% for COEPBF and 95% for COPAC.

Conclusions:

COEPBF exhibits reliable trending capabilities, comparable to PAC thermodilution.
Both COEPBF and COPAC showed low bias but high percentage errors.
Further validation in animal lung injury models and surgical patients is recommended.