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Updated: May 2, 2026
12:24
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
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Expression of CD20 in B Cell Precursor Acute Lymphoblastic Leukemia
Jeevan Kumar1, Afaq Ahmad Khan1, Amrita Saraf1
1Department of Hematology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India.
Summary
In Indian patients with B cell precursor acute lymphoblastic leukemia (BCP-ALL), 62% of cases expressed CD20. Further research is needed to guide rituximab use in CD20-positive BCP-ALL.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- CD20 is a B cell antigen with debated significance in B cell precursor acute lymphoblastic leukemia (BCP-ALL).
- Limited data exists on CD20 expression in Indian BCP-ALL patients.
Purpose of the Study:
- To evaluate CD20 expression in a cohort of Indian BCP-ALL patients.
- To assess the prevalence and intensity of CD20 expression in BCP-ALL.
Main Methods:
- Retrospective analysis of 100 BCP-ALL patients.
- CD20 expression assessed by flow cytometry, with positivity defined as ≥20% in the blast population.
Main Results:
- CD20 expression was observed in 62% of BCP-ALL patients.
- CD20 positivity varied from negative/dim (35.5%) to moderately bright (19.3%) and bright (45.2%).
- 38% of patients were CD20 negative.
Conclusions:
- CD20 is frequently expressed in Indian BCP-ALL patients.
- Prospective studies are required to determine the optimal role of rituximab in CD20-positive BCP-ALL.
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