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An association of leishmaniasis and dyserythropoiesis in children

Fatih Temiz1, Berrak Bilginer Gürbüz1, Göksel Leblebisatan1

  • 1Department of Pediatrics, Adana Numune Research and Education Hospital, Hacıomer Sabanci Street, Adana, Turkey.

Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion
|February 21, 2014
PubMed

Insights

Visceral leishmaniasis causes bone marrow changes, including dyserythropoiesis, in approximately half of affected children. Early recognition is crucial for accurate diagnosis and differentiation from other blood disorders.

Area of Science:

  • Hematology
  • Parasitology
  • Pathology

Background:

  • Visceral leishmaniasis (VL) is an infectious disease with significant hematological manifestations.
  • Hematological issues include cytopenias and coagulopathies.
  • VL also induces morphological alterations in the bone marrow.

Purpose of the Study:

  • To highlight the bone marrow morphological changes in children with visceral leishmaniasis.
  • To emphasize the prevalence of dyserythropoiesis in pediatric VL cases.
  • To alert physicians in endemic areas about these findings for differential diagnosis.

Main Methods:

  • Analysis of bone marrow aspirate slides from children diagnosed with visceral leishmaniasis.
  • Morphological examination of red blood cell precursors for dyserythropoietic features.

Main Results:

  • Dyserythropoiesis was observed in approximately 50% of pediatric VL patients.
  • Characteristic findings included multilobed nuclear cells and inter-nuclear bridges.
  • These morphological changes impact red blood cell development.

Conclusions:

  • Dyserythropoiesis is a prominent feature of visceral leishmaniasis in children.
  • Physicians in VL-endemic regions must be aware of these bone marrow findings.
  • Distinguishing VL-related dyserythropoiesis from other causes is essential for proper patient management.

Keywords:
ChildrenDyserythropoiesisLeishmaniasis

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