Bdellovibrio bacteriovorus : A future antimicrobial agent?

Bdellovibrio and like organisms (BALOs) are small, predatory, Deltaproteobacteria that prey on other Gram-negative pathogens. Many authors have unfolded the possible use of BALOs as biological control agents in environmental as well as medical microbiological settings. They are found strongly associated with natural biofilms and recent studies have shown that effective predation occurs in these naturally occurring bacterial communities. Periodontal infections could also be an interesting target for the application of BALOs as biological Gram-negative bacteria and therefore potentially susceptible to BALOs antimicrobial agents. This proposition is based on the fact that almost all periodontal pathogens are predation. Accordingly, this review aims to present the evolution toward applying Bdellovibrio bacteriovorus as an antibacterial agent to deal with oral infections, general medical conditions, environmental and industrial issues.