Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Social Loafing01:37

Social Loafing

29.3K
Another way in which a group presence can affect performance is social loafing—the exertion of less effort by a person working together with a group. Social loafing occurs when our individual performance cannot be evaluated separately from the group. Thus, group performance declines on easy tasks (Karau & Williams, 1993). Essentially individual group members loaf and let other group members pick up the slack. Because each individual’s efforts cannot be evaluated,...
29.3K
Design Example: Maintaining Level of an Embankment01:19

Design Example: Maintaining Level of an Embankment

548
Constructing a roadway embankment over uneven terrain requires precise leveling to ensure stability and proper drainage. Surveyors use a leveling instrument and staff to calculate ground elevations and determine the required fill material at each point along the embankment alignment.The process begins by positioning a leveling instrument near a benchmark with a known elevation. A backsight reading establishes the instrument height, which serves as a reference for subsequent measurements. A...
548
Framing Effects03:26

Framing Effects

7.8K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
7.8K
Design Example: Designing Water Slide01:18

Design Example: Designing Water Slide

794
When designing a water slide, controlling the speed of water flow is crucial for rider safety while maintaining an exciting experience. As water flows down the slide, gravity causes it to accelerate, with its speed at the bottom depending on the height from which it starts. The higher the slide, the more potential energy the water has at the top, which is converted into kinetic energy as it descends, increasing its speed.
Bernoulli's principle determines the water's velocity along the slide....
794
Conservation of Energy: Application01:12

Conservation of Energy: Application

5.7K
When solving problems using the energy conservation law, the object (system) to be studied should first be identified. Often, in applications of energy conservation, we study more than one body at the same time. Second, identify all forces acting on the object and determine whether each force doing work is conservative. If a non-conservative force (e.g., friction) is doing work, then mechanical energy is not conserved. The system must then be analyzed with non-conservative work. Third, for...
5.7K
Robbers Cave04:49

Robbers Cave

13.5K
During the 1950s, the landmark Robbers Cave experiment demonstrated that when groups must compete with one another, intergroup conflict, hostility, and even violence may result. At the Oklahoman summer camp, two troops of boys—termed the Rattlers and the Eagles—took part in a week-long tournament. During this time, their negativity culminated in derogatory name-calling, fistfights, and even vandalism and destruction of property. However, this work also revealed that such tension...
13.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Data-Driven Analysis of Fluorination of Ligands of Aminergic G Protein Coupled Receptors.

Biomolecules·2021
Same author

Introducing the metacore concept for multi-target ligand design.

RSC medicinal chemistry·2021
Same author

Systematic Data Analysis and Diagnostic Machine Learning Reveal Differences between Compounds with Single- and Multitarget Activity.

Molecular pharmaceutics·2020
Same author

Advances in exploring activity cliffs.

Journal of computer-aided molecular design·2020
Same author

Current Trends, Overlooked Issues, and Unmet Challenges in Virtual Screening.

Journal of chemical information and modeling·2020
Same author

Computational method for the identification of third generation activity cliffs.

MethodsX·2020
Same journal

Cyber Military Operations under International Humanitarian Law: Interpreting the Concept of "Attack" and Challenges in Protecting Civilians.

F1000Research·2026
Same journal

Sentiment Analysis of Acceptance TVET Online Courses on the Skill Academy App from Google Play: Leveraging Text Mining with Comparison Machine Learning Model.

F1000Research·2026
Same journal

Emotional intelligence: An important skill to learn now more than ever.

F1000Research·2026
Same journal

East Mediterranean Lineage of <i>Brucella melitensis</i> in Human Isolates and Milk Samples in Oman Using MLVA-14.

F1000Research·2026
Same journal

Application of K-Means Clustering for Job Applicant Analysis in Construction Firms Using R.

F1000Research·2026
Same journal

The influence of self-esteem and emotional intelligence on addiction to social networks in Peruvian university students.

F1000Research·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

Four Temporary Waterslide Designs Adapted to Different Slope Conditions to Encourage Child Socialization in Playgrounds
06:00

Four Temporary Waterslide Designs Adapted to Different Slope Conditions to Encourage Child Socialization in Playgrounds

Published on: December 9, 2022

2.5K

Advancing the activity cliff concept.

Ye Hu1, Dagmar Stumpfe1, Jürgen Bajorath1

  • 1Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology and Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universität, Bonn, D-53113, Germany.

F1000Research
|February 21, 2014
PubMed
Summary
This summary is machine-generated.

Activity cliffs, pairs of similar compounds with large potency differences, are crucial for drug discovery. Understanding these structure-activity relationship (SAR) insights aids in optimizing drug candidates.

More Related Videos

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance
07:19

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance

Published on: March 19, 2020

7.6K
A Training Program Using an Agility Ladder for Community-Dwelling Older Adults
14:13

A Training Program Using an Agility Ladder for Community-Dwelling Older Adults

Published on: March 7, 2020

10.2K

Related Experiment Videos

Last Updated: May 2, 2026

Four Temporary Waterslide Designs Adapted to Different Slope Conditions to Encourage Child Socialization in Playgrounds
06:00

Four Temporary Waterslide Designs Adapted to Different Slope Conditions to Encourage Child Socialization in Playgrounds

Published on: December 9, 2022

2.5K
A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance
07:19

A Modified Lean and Release Technique to Emphasize Response Inhibition and Action Selection in Reactive Balance

Published on: March 19, 2020

7.6K
A Training Program Using an Agility Ladder for Community-Dwelling Older Adults
14:13

A Training Program Using an Agility Ladder for Community-Dwelling Older Adults

Published on: March 7, 2020

10.2K

Area of Science:

  • Medicinal Chemistry
  • Chemoinformatics
  • Computational Drug Discovery

Background:

  • Activity cliffs are pairs of structurally similar compounds with significant potency differences against the same biological target.
  • These cliffs are vital for understanding structure-activity relationships (SAR) and guiding compound optimization in drug development.
  • Systematic identification of activity cliffs can be achieved through mining large compound activity datasets.

Purpose of the Study:

  • To provide a comprehensive overview of the current understanding of the activity cliff concept.
  • To introduce a refined activity cliff concept to a broader audience in drug development.
  • To highlight the importance of activity cliffs in medicinal chemistry and chemoinformatics.

Main Methods:

  • Review and synthesis of existing literature on activity cliffs.
  • Discussion of systematic identification methods through data mining.
  • Explanation of the refined activity cliff concept.

Main Results:

  • Activity cliffs offer valuable insights into how minor chemical modifications impact drug potency.
  • Systematic data mining enables broader identification of activity cliffs beyond individual compound series.
  • A refined understanding of activity cliffs enhances their utility in drug design.

Conclusions:

  • Activity cliffs are a key phenomenon in medicinal chemistry for optimizing drug candidates.
  • Systematic analysis of activity cliffs accelerates the drug discovery and development process.
  • The refined activity cliff concept offers enhanced value for drug developers.