Related Experiment Video
Updated: May 2, 2026
05:12
Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model
Published on: September 4, 2017
10.0K
Multicystic meningioangiomatosis
Peifeng Li, Guangbin Cui, Yingmei Wang
1Department of Pathology, General Hospital of Jinan Military Command, Ji'nan 250031, China. gm2227@sina.com.
BMC Neurology
|February 22, 2014
Summary
Meningioangiomatosis (MA) is a rare brain lesion. This case highlights a multicystic form, emphasizing surgical resection and electrocorticography for seizure control and diagnosis.
Area of Science:
- Neuropathology
- Neurosurgery
- Developmental Neurobiology
Background:
- Meningioangiomatosis (MA) is a rare hamartomatous lesion.
- Cystic variants of MA are exceptionally rare, with only six cases previously reported.
Observation:
- A 21-year-old woman presented with intractable seizures due to a right temporal lobe multicystic mass.
- Magnetic resonance imaging revealed a well-defined, heterogeneous lesion.
- Histopathology showed perivascular cell proliferation, microcysts, and novel hyalinized collagen fibers.
Findings:
- The multicystic MA exhibited unique histopathological features, including hyalinized collagen fibers.
- Surgical resection of the lesion and epileptogenic cortex was performed with intraoperative electrocorticography (ECoG) assistance.
- The patient remained symptom-free with no recurrence for 2 years post-surgery.
Implications:
- MA may arise from trapped arachnoid and vascular tissue during brain development.
- Cysts likely form from cerebrospinal fluid accumulation in perivascular spaces.
- Surgical resection and ECoG are crucial for diagnosis and seizure management in MA.
Related Concept Videos
01:18Viral Meningitis
199
Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
199
01:26Bacterial Meningitis II: Pathophysiology
24
Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
24
01:27Cytomegalovirus Disease
102
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
01:22Cerebral Edema ll: Pathophysiology
19
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this...
19
01:19Cranial and Spinal Meninges
4.5K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.5K
01:22Bacterial Meningitis I: Introduction
15
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
15