Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The effect of altered thyroid function on serum fructosamine concentrations.

R Cirillo1, S Balzano, E Cossu

  • 1Cattedra di Clinica Medica I, University of Cagliari, Italy.

Clinical Biochemistry
|June 1, 1988
PubMed
Summary

Hypothyroidism significantly increases serum fructosamine levels, while hyperthyroidism does not. This finding is crucial for interpreting diabetes management in patients with thyroid dysfunction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

LAG3 as a potential biomarker in breast cancer: integrated tissue and peripheral blood analysis reveals clinical and pathomic insights in triple-negative disease.

Journal of translational medicine·2026
Same author

Cellular senescence as a prognostic marker for predicting breast cancer progression in 2D and 3D organoid models.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2025
Same author

Nutritional ecology of a prototypical generalist predator, the red fox (Vulpes vulpes).

Scientific reports·2024
Same author

The multidimensional prognostic index (MPI) predicts long-term mortality in old type 2 diabetes mellitus patients: a 13-year follow-up study.

Journal of endocrinological investigation·2023
Same author

The human carotid atherosclerotic plaque: an observational review of histological scoring systems.

European review for medical and pharmacological sciences·2023
Same author

The role of fetal programming in human carcinogenesis - May the Barker hypothesis explain interindividual variability in susceptibility to cancer insurgence and progression?

European review for medical and pharmacological sciences·2022

Area of Science:

  • Endocrinology
  • Clinical Chemistry

Background:

  • Thyroid hormones regulate numerous metabolic processes.
  • Serum fructosamine is a marker for long-term glycemic control, reflecting average blood glucose over 2-3 weeks.
  • The impact of thyroid dysfunction on serum fructosamine requires clarification.

Purpose of the Study:

  • To investigate the effect of hyperthyroidism and hypothyroidism on serum fructosamine concentrations.
  • To compare serum fructosamine levels in patients with different thyroid states and healthy controls.
  • To assess the influence of thyroid hormone replacement and normalization on serum fructosamine.

Main Methods:

  • Cross-sectional study comparing serum fructosamine in untreated hyperthyroid, short-term hypothyroid, long-term hypothyroid patients, and normal controls.

Related Experiment Videos

  • Analysis of serum fructosamine concentrations across different patient groups.
  • Observation of changes in serum fructosamine following L-Thyroxine (L-T4) therapy in hypothyroid patients and antithyroid drug therapy in hyperthyroid patients.

    • Main Results:

    • Serum fructosamine concentrations were not significantly different between hyperthyroid patients and normal controls.
    • Serum fructosamine concentrations were significantly higher in both short-term and long-term hypothyroid patients compared to normal controls.
    • Long-term hypothyroid patients exhibited higher serum fructosamine levels than short-term hypothyroid patients, suggesting duration is a factor.

    Conclusions:

    • Hypothyroidism is associated with a significant increase in serum fructosamine concentrations.
    • The observed increase in serum fructosamine in hypothyroidism is not explained by major changes in plasma protein or glucose metabolism.
    • Caution is advised when interpreting elevated serum fructosamine as a sole indicator of diabetes mellitus control in hypothyroid individuals.