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Focal therapy for prostate cancer. Rationale, indications and selection
F Gómez-Veiga1, P Portela-Pereira1, J M Cozar-Olmo2
1Servicio de Urología, Hospital Universitario de Salamanca y Complejo Hospitalario Universitario de A Coruña, A Coruña, España.
Actas Urologicas Espanolas
|February 22, 2014
Summary
Focal therapy offers an alternative for localized prostate cancer treatment. Further prospective studies are needed to refine patient selection and diagnostic criteria for optimal outcomes.
Area of Science:
- Oncology
- Urology
Background:
- Localized prostate cancer treatment involves a debate between radical options and active surveillance.
- Focal therapy presents a potential alternative treatment modality.
Purpose of the Study:
- To analyze the rationale for selecting patients and tumors for current focal therapy methods.
- To review the advantages and disadvantages of focal therapy for localized prostate cancer.
Main Methods:
- A review of current articles on localized prostate cancer treatment options.
- MEDLINE search for information on focal therapy, tumor selection, and indications.
Main Results:
- Standardized criteria for focal therapy include low-risk tumors, PSA < 10-15, Gleason score ≤ 6, and unilateral presentation.
- Image-guided biopsy and nuclear magnetic resonance (NMR) are crucial for diagnosis.
- Suitability is questionable for bilateral disease or higher Gleason scores (3+4) or PSA > 15.
Conclusions:
- Focal therapy is a viable alternative for localized prostate cancer.
- Prospective studies are essential to establish definitive diagnostic and selection criteria for focal therapy indications.
