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Paliperidone-associated motor tics

Ming-Han Hsieh1, Nan-Ying Chiu2

  • 1Department of Psychiatry, Lutong Christian Hospital, Lukang Township, Changhua County, Taiwan.

General Hospital Psychiatry
|February 22, 2014
PubMed
Abstract

Insights

Paliperidone, an antipsychotic medication, can cause motor tics, such as eye blinking, in patients with schizophrenia. High doses of paliperidone may increase the risk of developing these tic-like symptoms.

Area of Science:

  • Psychiatry
  • Clinical Pharmacology

Background:

  • Paliperidone is a widely used second-generation antipsychotic for treating schizophrenia.
  • Understanding its side effect profile is crucial for patient management.

Observation:

  • A case report details a 30-year-old male diagnosed with schizophrenia.
  • The patient developed motor tics, specifically eye blinking, during paliperidone treatment.

Findings:

  • The onset of motor tics was associated with paliperidone administration, reaching a daily dosage of 15 mg.
  • This suggests a potential link between paliperidone and the development of tic disorders.

Implications:

  • Clinicians should be vigilant for tic-like symptoms, ranging from simple eye blinking to Tourette-like syndrome, in patients treated with paliperidone.
  • Dose-dependent effects may be a factor, warranting careful titration and monitoring, especially at higher paliperidone doses.
Keywords:
Atypical antipsychoticsMotor ticsPaliperidone

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