Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy ll: Types01:22

Epilepsy ll: Types

47
Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
47
Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.7K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K
Seizures: Classification01:13

Seizures: Classification

2.5K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.5K
Seizures ll: Types01:19

Seizures ll: Types

36
Seizures are sudden bursts of abnormal electrical discharge in the brain that interfere with normal function. They are commonly divided into three groups: focal seizures, generalized seizures, and other types that do not fit neatly into either category.Focal SeizuresFocal seizures begin in a single brain region. When awareness is preserved, they are called focal aware seizures and may cause sensations such as tingling, unusual smells, or flashing lights. When awareness is impaired, they are...
36
Seizures l: Introduction01:20

Seizures l: Introduction

42
Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
42
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

1.7K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuropsychological correlations with fornix and hippocampus in temporal lobe epilepsy demonstrated with diffusion tensor imaging.

Epilepsia open·2026
Same author

Rapid 1 mm isotropic diffusion tensor imaging with denoising and improved parameter estimation for detecting focal hippocampal lesions in temporal lobe epilepsy.

Magnetic resonance imaging·2025
Same author

Longitudinal hippocampal diffusion-weighted imaging and T2 relaxometry demonstrate regional abnormalities which are stable and predict subfield pathology in temporal lobe epilepsy.

Epilepsia open·2022
Same author

Hippocampal subfield measurement and ILAE hippocampal sclerosis subtype classification with in vivo 4.7 tesla MRI.

Epilepsy research·2020
Same author

Regional hippocampal diffusion abnormalities associated with subfield-specific pathology in temporal lobe epilepsy.

Epilepsia open·2019
Same author

Successful management of postictal violence with pindolol in temporal lobe epilepsy.

Epilepsy & behavior reports·2019
Same journal

From electroclinical phenotype to adult SCN1A diagnosis: Insights from the correspondence between Carlo Alberto Tassinari and Charlotte Dravet.

Epileptic disorders : international epilepsy journal with videotape·2026
Same journal

NMDAR-antibody encephalitis: Seizure semiology and EEG findings.

Epileptic disorders : international epilepsy journal with videotape·2026
Same journal

Asymmetric sleep spindles after thalamic stroke.

Epileptic disorders : international epilepsy journal with videotape·2026
Same journal

Complete seizure freedom following minimally invasive laser callosotomy in a patient with lissencephaly type 1: Challenging the traditional paradigm.

Epileptic disorders : international epilepsy journal with videotape·2026
Same journal

Predictors of long-term seizure outcomes and perceived quality of life outcomes after temporal lobe epilepsy surgery.

Epileptic disorders : international epilepsy journal with videotape·2026
Same journal

Age-dependent electroclinical evolution from focal seizures to epileptic spasms in NUSAP1-related malformations of cortical development.

Epileptic disorders : international epilepsy journal with videotape·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.5K

Alcohol-responsive epilepsia partialis continua.

Trevor A Steve1, Donald W Gross1

  • 1Division of Neurology, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

Epileptic Disorders : International Epilepsy Journal with Videotape
|February 22, 2014
PubMed
Summary
This summary is machine-generated.

Epilepsia partialis continua, a rare seizure disorder, can stem from subcortical lesions. A patient showed unique responses to alcohol and primidone, suggesting a shared network with essential tremor.

Keywords:
epilepsia partialis continuaessential tremormyoclonustremor

More Related Videos

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

17.3K
Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

9.9K

Related Experiment Videos

Last Updated: May 2, 2026

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
09:57

Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization

Published on: September 20, 2024

3.5K
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

17.3K
Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
04:51

Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy

Published on: April 11, 2019

9.9K

Area of Science:

  • Neurology
  • Neuroscience
  • Pathophysiology

Background:

  • Epilepsia partialis continua (EPC) is characterized by continuous focal motor seizures, typically linked to cerebral cortical lesions.
  • While cortical involvement is common, subcortical lesions can also precipitate EPC, presenting diagnostic and therapeutic challenges.

Observation:

  • A case of EPC resistant to standard anticonvulsants is presented.
  • The patient exhibited a notable, albeit temporary, response to alcohol and a subsequent, sustained response to primidone.

Findings:

  • The observed sensitivity pattern to alcohol and primidone mirrors that seen in essential tremor.
  • This suggests a potential shared anatomical network or pathophysiological mechanism between EPC and essential tremor.

Implications:

  • The findings support a novel pathophysiological model for EPC, encompassing both cortical and subcortical origins.
  • This could lead to new therapeutic strategies targeting specific neural networks for refractory EPC.