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Updated: May 2, 2026

Using Caenorhabditis elegans as a Model System to Study Protein Homeostasis in a Multicellular Organism
Published on: December 18, 2013
Systemic stress signalling: understanding the cell non-autonomous control of proteostasis
Rebecca C Taylor1, Kristen M Berendzen1, Andrew Dillin1
1Howard Hughes Medical Institute, University of California Berkeley, Berkeley, California 94720, USA.
Abstract:
Proteome maintenance is crucial to cellular health and viability, and is typically thought to be controlled in a cell-autonomous manner. However, recent evidence indicates that protein-folding defects can systemically activate proteostasis mechanisms through signalling pathways that coordinate stress responses among tissues. Coordination of ageing rates between tissues may also be mediated by systemic modulation of proteostasis. These findings suggest that proteome maintenance is a systemically regulated process, a discovery that may have important therapeutic implications.
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