H. pylori infection, inflammation and gastric cancer
Qurteeba Qadri1, Roohi Rasool, G M Gulzar
1Department of Immunology and Molecular Medicine, Sher-i-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Jammu and Kashmir, 190011, India, qurteebaqadri@gmail.com.
Introduction:
A strong association between chronic infection, inflammation, and cancer has been suggested.
Discussion:
Helicobacter pylori, a microaerophilic gram negative bacterium, infects about half the world's population. It has been defined as a definitive carcinogen in the pathogenesis of gastric cancer. H. pylori evades the host immune responses and persists in the stomach leading to gastritis gastric atrophy and sometimes gastric cancer.
Conclusion:
Chronic H. pylori infection causes gastric cancer via two mechanisms: the presence of virulence factors and the induction of chronic inflammation which ultimately leads to neoplastic transformation.
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