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Updated: May 2, 2026
Detection of Nitric Oxide and Superoxide Radical Anion by Electron Paramagnetic Resonance Spectroscopy from Cells using Spin Traps
Published on: August 18, 2012
Novel reversible and selective nerve agent simulant detection in conjunction with superoxide "turn-on" probing
Yoon Jeong Jang1, Dhiraj P Murale, David G Churchill
1Department of Chemistry Molecular Logic Gate Laboratory, Korea Advanced Institute of Science and Technology (KAIST), 373-1 Guseong-dong, Yuseong-gu, Daejeon, 305-701, Republic of Korea. dchurchill@kaist.ac.kr.
Abstract:
Herein, we present fluorescein as a reversible fluorescent sensor for nerve agent simulants diethylchlorophosphate (DCP), diethyl methylphosphonate (DEMP), and diethyl cyanophosphonate (DECP). The superoxide allows for an "off-on" mechanism to regenerate fluorescein. The order of decrease in fluorescence intensity for nerve agent simulants is DCP > DEMP ≫ DECP.
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