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Related Experiment Video

Updated: May 2, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

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Published on: April 7, 2023

[Osteoporosis].

Brigitte Uebelhart¹, René Rizzoli²

¹Service des maladies osseuses, Département des spécialités de médecine, HUG, 1211 Genève. brigitte.uebelhart@hcuge.ch

Revue Medicale Suisse

|February 25, 2014

Summary

This summary is machine-generated.

Osteoporosis management quality differs globally. Calcium intake shows no clear cardiovascular risk, while zoledronic acid has lasting effects and Denosumab has no early fracture risk upon cessation.

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Area of Science:

Endocrinology
Bone Metabolism
Cardiovascular Health

Background:

Osteoporosis management quality varies internationally.
Swiss guidelines utilize the FRAX tool for intervention thresholds.
Cardiovascular risks associated with osteoporosis treatments are under scrutiny.

Purpose of the Study:

To evaluate the quality of osteoporosis management.
To assess cardiovascular disease risk with calcium intake.
To determine the duration of zoledronic acid's effect and Denosumab's safety profile post-cessation.

Main Methods:

Review of international osteoporosis management quality.
Analysis of observational studies on calcium intake and cardiovascular disease.
Assessment of persistent effects of zoledronic acid.
Evaluation of fracture risk after Denosumab cessation.

Main Results:

Calcium intake does not show a clear increased cardiovascular disease risk.
Zoledronic acid demonstrates a persistent therapeutic effect post-single injection.
No increased fracture risk was observed within 7 months of Denosumab discontinuation.

Conclusions:

Osteoporosis treatment effectiveness and safety profiles require ongoing evaluation.
Current evidence does not link calcium intake to increased cardiovascular risk.
Zoledronic acid and Denosumab offer distinct safety and efficacy profiles in osteoporosis management.