Related Experiment Video
Updated: May 2, 2026

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
Published on: December 17, 2019
New treatment options for chronic lymphocytic leukemia
Julio Delgado1, Tycho Baumann, Rodrigo Santacruz
1University of Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Institute of Hematology and Oncology, Hospital Clínic, Department of Hematology , Villaroel 170, 08036 Barcelona , Spain +34 93 227 54 75 ; +34 93 227 98 11 ; emontse@clinic.ub.es.
Introduction:
Chemoimmunotherapy is the gold standard of therapy for patients with advanced chronic lymphocytic leukemia (CLL), resulting in high and durable complete response rates. However, all patients eventually relapse and CLL remains incurable. Newer and more rationally developed compounds are needed to improve CLL therapy, particularly in cases of refractory disease.
Areas Covered:
Following a literature search on PubMed using 'chronic', 'lymphocytic', 'treatment' and 'therapy' as keywords, results obtained with novel agents were critically analyzed. Abstracts presented during 2013 at ASH, EHA, ICML, IWCLL and ASCO meetings were also included in the search.
Expert Opinion:
New monoclonal antibodies, lenalidomide, B-cell receptor-signal transduction inhibitors and pro-apoptotic molecules have shown efficacy in patients with relapsed or refractory disease. Hopefully, the combined use of these molecules in risk-adapted treatment strategies will improve the outcome of patients with CLL and pave the way for their long-term control.
More Related Videos
09:02Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
09:34Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
Published on: February 17, 2022
Related Concept Videos
Targeted Cancer Therapies
There are several types of targeted therapies against...
Treatment Resistant Cancers
Tumor Immunotherapy
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...