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Updated: May 2, 2026

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Skin as an indicator for sexually transmitted infections
1STI Outpatient Clinic, Cluster of Infectious diseases, Public Health Service Amsterdam, Amsterdam, The Netherlands; Department of Dermatology, Academic Medical Center, Post Office Box 22700, 1100 DE, University of Amsterdam, Amsterdam, The Netherlands; Centre for Infection and Immunity Amsterdam (CINIMA) Academic Medical Centre University of Amsterdam, Amsterdam, The Netherlands; Centre for Infectious Diseases Control; National Institute for Public Health and the Environment (CIb/RIVM), Bilthoven, The Netherlands.
Sexually transmitted infections (STIs) often present with distinct skin conditions. Dermatologists play a crucial role in diagnosing STIs like syphilis, HIV, and HPV-related conditions, impacting prognosis and transmission.
Area of Science:
- Dermatology
- Infectious Diseases
- Public Health
Background:
- Sexually transmitted infections (STIs) frequently manifest with characteristic cutaneous signs and symptoms.
- Several STIs, including syphilis, condyloma acuminata (genital warts), scabies, chlamydia, gonorrhea, and HIV, are known to have dermatological implications.
- Skin conditions are often the initial presentation of HIV infection, highlighting the dermatologist's role in early diagnosis and management.
Purpose of the Study:
- To discuss the cutaneous manifestations of various sexually transmitted infections (STIs).
- To emphasize the critical role of dermatologists in the diagnosis, prognosis, and transmission control of STIs, particularly HIV.
- To raise awareness about emerging conditions like anal intraepithelial neoplasia (AIN) in the context of STIs and HIV.
Main Methods:
- Review of known cutaneous signs and skin conditions associated with common and emerging STIs.
- Discussion of the diagnostic and prognostic importance of dermatological findings in STIs, especially HIV.
- Highlighting the relevance of considering STIs in the differential diagnosis of anogenital dermatoses.
Main Results:
- Syphilis, condyloma acuminata, and scabies are prominent STIs with visible skin manifestations.
- Chlamydia, gonorrhea, and HIV infections can present with specific muco-cutaneous signs.
- Dermatologists are essential for early HIV diagnosis, influencing patient outcomes and preventing further transmission.
Conclusions:
- Cutaneous manifestations are key indicators for diagnosing various STIs.
- Dermatologists are vital in managing STIs, including recognizing HIV-related skin conditions and precursors to anal cancer like AIN.
- Anogenital dermatoses, particularly in high-risk individuals, warrant a thorough differential diagnosis including STIs.
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